Pertussis is a respiratory transmitted disease affecting approximately
23% of the worlds’ population. It is causes by Bordetella Pertussis. The
emergence of Multiple Drug Resistant (MDR) Pertussis has focused the attention
of the scientific community thought the world on the urgent need for new
anti-Pertussis drugs.
In pursuit of this goal, our research efforts are directed
toward the discovery of new chemical entities that are effective
as anti-Pertussis drugs. During recent years, there have been intense investigations of
different classes of 1,3,4- thiadiazole-2-sulfonamide compounds and derivatives
such as 5- [(Phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide many of which
are known to possess interesting pharmaceutical, biological, biochemical and
biomedical properties suchlike anti–microbial, anti– Pertussis and
anti–inflammatory activities.
It should be noted that the purity of the synthesized
compound was confirmed by High Performance Liquid Chromatography (HPLC) and
also Thin–Layer Chromatography (TLC).
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