Hearing loss is a
problem with higher incidence in South Asia, Asia Pacific and sub-Saharan
Africa. In these countries there is also associated history of anemia and
malaria.
This study aims
to identify a putative role of Beta globin mutation - sickle cell trait and HL
in São Tomé and Príncipe population. A retrospective case-control study of a
convenience sample was collected during Otolaryngologist Humanitarian
Missions in São Tomé and Príncipe. Control group
includes individuals with normal hearing in both ears, and the case group has
participants presenting bilateral or unilateral HL.
It was evaluated
the potential risk factors and sickle cell trait with HL, as well self-report
of malaria infection, consanguinity, familial history of HL. The HbS gene point
mutation (Glu6Val) was determined by PCR-RFLP. Results: Our results showed a
statistical significance between HL - oral language and self-report of HL.
Taken altogether, our data did not reveal association between sickle cell trait
and HL.
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