Human mankind is
aware of the existence of adverse reactions to foods since classical times.
Hippocrates (460-370 BC) reported urticaria and gastrointestinal upset
following cow's milk (CM) ingestion.
Lucretius (98-55
BC) wrote "Quod aliiscibus estaliis fuatacre venenum". Galen (131-
219) described allergy to goat's milk. At the turn of this century the first
description of acute shock due to CM allergy was published, and Schloss was the
first to evaluate skin tests for the diagnosis.
Accordingly the
aspiration to influence the natural incidence of atopic illness has piqued
physicians' imaginations for a long time. The phenotypic expression of
IgE-mediated disorders, which appears regulated by multiple genetic factors and
modulated by environmental experiences, has been a target for prevention
medicine since the 1920s when dietary intervention was adopted in infancy.
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