The
use of uncemented titanium endosseous implants for restorative dentistry and
orthopaedic surgery has been the standard of care for several decades.
Still,
the mechanisms involved in this fascinating and unique interaction between a
living tissue and foreign substance are poorly understood. An important
reason for the absence of sufficient mechanistic information is the lack of
robust experimental models combined with solid tools to analyze
structurefunction relationships of the implant-bone system.
Qualitative
and quantitative ex vivo analysis of peri-implant tissues is typically done by
means of light microscopy using thin histological sections following implant
removal or thicker ground sections which contain the implant and undecalcified
bone.
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