Monday, 12 September 2016

Plasma Concentration of Oxycodone and Pain during Hemodialysis in a Patient with Cancer

A 55-year-old man with a history of lung cancer, liver metastasis, a liver abscess, and glomerulonephritis (RPGN) associated with methicillin-resistant Staphylococcus aureus (MRSA) infection presented at our department. He underwent a right upper lobectomy, with resection of the parietal pleura, for right lung cancer. He had a recurrence of the cancer, liver metastasis, and a liver abscess postoperatively, and was treated via a left hepatic lobectomy for the metastastic liver tumor. Oxycodone (Oxycontin®; 80 mg/day) was used to treat severe pain in his right chest.

Hemodialysis in a Patient with Cancer
He didn’t receive drugs which influence the metabolism of oxycodone such as CYP3A4 and CYP2D6 inhibitors and inducers. Elevated serum creatinine, proteinuria, and hematuria indicated glomerulonephritis-induced renal failure. He then presented at our department for pain control during hemodialysis.He presented to us with pain in his right chest, right back, and right arm. The right chest and back pain were intermittent sharp pains, and localized in his right precordia and around his scapula.


The maximum, minimum, and average pain scores based on the 0–10 numeric rating scale (NRS) were 4/10, 2/10 and 2/10 respectively. Neither neurological disturbances, hypaesthesia, nor listlessness was identified, and the douleur neuropathique 4 questions (DN4) score was a 0/10. We therefore diagnosed these right chest and back pains as somatalgia. However, the right arm pain was continuous and intermittent, relatively sharp, and localized in the area supplied by the ulnar nerve. No shooting pain was identified.

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