Wednesday, 14 September 2016

Do Not Resuscitate: An Argumentative Essay

The primary health care provider goal is to restore patients' health as possible by maximizing benefits and minimizing harm. Accordingly if treatment failed, the harm or burden will be more than benefits. On the other hand, if the competent patient refused treatment; that treatment is no longer justified. Unfortunately, many physicians do not know their patients’ preferences for resuscitation, and many patients have a poor understanding of their own resuscitation order.
General Medicine

Nurses as an essential part of the health care provider have always been beside of dying patients, their roles in providing the maximum quality of care and support for the remaining lifetime for both patients and their loved ones is traditional and expected. The nurse’s loyalty to the patient requires an expertise in the relief of physical, emotional, or spiritual suffering, which means the nurse’s roles in discussions end of life choices with patients is imminent.
Death is defined in Black’s Law Dictionary as an irreversible cessation of the vital functions, signs, circulation, and pulsation. For that if your patient stops breathing or their heart stops beating in the hospital, it is generally felt that the morally best approach is to perform Cardiopulmonary Resuscitation (CPR). However, success is not always possible, and not uncommon, this procedure is associated with a high level of morbidity but it's must be ethically justified.

Tuesday, 13 September 2016

Comparison of KTP Laser Turbinate Reduction with Surgical Turbinoplasty in the Management of Inferior Turbinate Hypertrophy: A Randomised Controlled Clinical Trial

Inferior turbinate hypertrophy is one of the commonest causes of nasal obstruction. Several surgical methods are used for thereduction of inferior turbinate hypertrophy refractory to medical management. This study compared KTP laser turbinate reduction andsurgical turbinoplasty procedures.Materials and Methods This study was carried out in JIPMER, Puducherry from November 2011 to March 2013. Patients attending ENTOPD with inferior turbinate hypertrophy who were refractory to medical management were selected.
KTP Laser Turbinate Reduction

They were randomized into twogroups. Group 1 underwent KTP laser turbinate reduction Group 2 underwent Surgical turbinoplasty.Total of 60 patients were selected for the study. Onepatient lost to follow up. Hence 59 patients were considered for the study. Outof the 59 patients 29 underwent KTP laser turbinate reduction and 30 underwent Surgical turbinoplasty. Both the procedures were found tobe equally effective in terms of improvement of the symptoms associated with inferior turbinate hypertrophy.

 KTP laser turbinate reductionhad shorter operation time compared to surgical turbinoplasty and were associated with no serious intra operative or post operativecomplications.Both KTP laser turbinate reduction and surgical turbinoplasty procedures are equally effective in the treatment of inferior turbinate hypertrophy. Both the procedures are safe, minimally invasive and well tolerated by the patients.


Monday, 12 September 2016

Plasma Concentration of Oxycodone and Pain during Hemodialysis in a Patient with Cancer

A 55-year-old man with a history of lung cancer, liver metastasis, a liver abscess, and glomerulonephritis (RPGN) associated with methicillin-resistant Staphylococcus aureus (MRSA) infection presented at our department. He underwent a right upper lobectomy, with resection of the parietal pleura, for right lung cancer. He had a recurrence of the cancer, liver metastasis, and a liver abscess postoperatively, and was treated via a left hepatic lobectomy for the metastastic liver tumor. Oxycodone (Oxycontin®; 80 mg/day) was used to treat severe pain in his right chest.

Hemodialysis in a Patient with Cancer
He didn’t receive drugs which influence the metabolism of oxycodone such as CYP3A4 and CYP2D6 inhibitors and inducers. Elevated serum creatinine, proteinuria, and hematuria indicated glomerulonephritis-induced renal failure. He then presented at our department for pain control during hemodialysis.He presented to us with pain in his right chest, right back, and right arm. The right chest and back pain were intermittent sharp pains, and localized in his right precordia and around his scapula.


The maximum, minimum, and average pain scores based on the 0–10 numeric rating scale (NRS) were 4/10, 2/10 and 2/10 respectively. Neither neurological disturbances, hypaesthesia, nor listlessness was identified, and the douleur neuropathique 4 questions (DN4) score was a 0/10. We therefore diagnosed these right chest and back pains as somatalgia. However, the right arm pain was continuous and intermittent, relatively sharp, and localized in the area supplied by the ulnar nerve. No shooting pain was identified.

Friday, 9 September 2016

Paracrine Insulin-like Growth Factor Binding Protein-3 Acts as Pro-apoptotic Factor for Leydig cells in the Rat Testis

Insulin-like growth factors (IGFs) are involved in cell metabolism, growth, differentiation, and survival in most organs, including those of the reproductive axis. The activities of these factors are regulated by a family of six high affinity-binding proteins (IGFBP-1–6), which determine IGF bioavailability in circulating fluids and the cellular environment.

IGFBP-3 is the most abundant circulating IGF-binding protein and mediates IGF independent actions on cell survival and apoptosis. In the testis, IGFs and IGFBPs are localized in the same cells that express LH and FSH receptors. IGFBP-2 and -3 are the most abundant IGFBPs in this organ and large amounts of IGFBP-3 are produced by Sertoli and Leydig cells. Both FSH and (Bu)2cAMP markedly lower IGFBP-3 levels in Sertoli cells and this binding protein can either inhibit or enhance the effects on Leydig cells steroidogenesis depending on the surrounding conditions.

The involvement of IGFBP-3 in steroidogenesis, development, and tumor growth in the testis is poorly understood. Previous investigations have revealed that IGFBP-3, -4, and -2 are predominantly expressed by Leydig cells. It has been proposed that IGFBP-3 also potentiates the inhibitory effects of cytokines on steroidogenesis. Both IGFBP-3 and -4 have been reported to be down-regulated in testicular seminomas, allowing more rapid tumor growth.

Thursday, 8 September 2016

Stercoral Colitis Associated with Colon Perforation

A 68 year-old woman presented with lower abdominal pain for three days and constipation for 10 days. The patient had a history of end-stage renal disease under regular hemodialysis, and coronary artery disease with antiplatelet drug. Physical examination was unremarkable except rebounding tenderness over lower abdomen. Blood tests showed bandemia 9% in white blood cell counts and elevated C-reactive protein (>250 mg/L, reference value, <3 mg/L).

Stercoral Colitis
Abdominal radiography showed sign of retroperitoneal air - the presence of air outlining the psoas muscle (Figure 1, arrow) and one gas-contenting abscess at left lower quadrant abdomen. Computed tomography (CT) of the abdomen revealed a large amount of fecaloma within sigmoid colon with wall thickening and pericolic fat stranding, and extravasation of stool material at left pelvic region (Figure 2, arrow), and pneumoretroperitoneum extending from the lower abdominal abscess.


Under the impression of stercoral colitis associated sigmoid colon perforation, emergent exploratory laparotomy was performed. One 1.6*1 cm perforation of sigmoid colon with abscess formation was found. The pathologic report of colon resection specimen shows aggregates of hemosiderin-laden macrophages in colonic mucosa with focal transmural necrosis. The post-operation course was smooth, and the patient was discharge uneventfully twelve days later.

Wednesday, 7 September 2016

Treatment of Urinary Incontinence in Women


About 40% of all women will develop urinary incontinence during their life, usually starting around the age of 50 years. It usually starts with the spontaneous undesired loss of urine during increased intra-abdominal pressure (coughing or sneezing) and will continue in even shorter time intervals to reach the toilet “just in time”. In its ultimate form the patient has no control anymore about her voiding function and is “always wet”.


Urinary Incontinence in Women

This is a totally debilitating disorder, which massively restricts the social and private life of the affected patient. Every pharmacologic treatment attempts to reduce the urinary incontinence symptoms; however, there was no cure achieved so far.

In 1996 Petros and Ulmsten hypothesized that urinary incontinence (UI) in women is caused by the laxity of the anterior vaginal wall. In that respect the pubourethral (PUL) and the uterosacral ligaments (USL) play a major role, as they are a substantial part of the holding apparatus of the vagina. According to the “bridge allegory” they are the “tows at the pylons which keep the vagina in the correct position.

Friday, 26 August 2016

Portable EEG-Based Music Effects

Music, by any definition, has been part of human life since the beginning of bipedalism, and maybe even before that. Now, in our 21st Century, there is not a day that goes by without music and without the myriad of technologies to help even an infant be exposed to this aesthetic form of communication. Music is energy, emotion, vibration, infiltrating our sensorysystems, emotions, and whole bodies. And, with the development of current technologies, music has a far reaching effect for composers developing unimaginable sounds and expressions and listener seeking the best devices for enjoying music.

Research on music in the sciences and medicine is finally reaching the forefront of attempts to understand the brain, cognition, physiology, and emotional behaviors. As a result of the birth of such scientific and engineering music explorations, this unique Journal of Biomusical Engineering has been put forth as a new platform for researchers and philosophers in and about music in human adaptation, to publish their thoughts and findings and reach a whole new, cross-modal audience of readers. 

EEG-Based Music Effects
This Journal especially provides an opportunity for younger researchers to present their work in an International journal that welcomes and nurtures fresh new ideas, thoughts, approaches to understanding the phenomenon of music in human existence. From Music Anthropology to Musicology, from Music Composition and expression to Music-based Treatment modalities, the Journal of Biomusical Engineering is the only on-line, free-access publication giving voice to an amalgam of researchers in Music and Physiologic Function, Music and Technology, Music in Treatment, Music in Cultural Expression, Music and Emotion, Music in history, and all areas of music in human behaviors.Read more......