Efficacy and Safety of Slowly Infused Propofol Sedation in Pediatric Oncology Procedures

Invasive procedures such as bone marrow aspiration and lumbar puncture are essential components for pediatric hematology and oncology patients. Pediatric patients who undergo invasive procedures often require sedation to prevent excessive motion, pain, and anxiety. 

Although several pharmacological agents have been used for these procedures, a standard has not yet been established. Ideal pharmacological agents have a rapid-onset of action, easily adjustable level of sedation, maintain cardiorespiratory function, and a short duration of activity once their administration is discontinued. Midazolam and ketamine (midazolam/ketamine) have traditionally been used for childhood invasive procedures in our hospital. 

Although midazolam and ketamine effectively achieve the desired sedation levels for childhood invasive procedures, both of those drugs have a long half-life such that sedation may persist for an excessively long time after the procedure has been completed.