The use of uncemented titanium
endosseous implants for restorative dentistry and orthopaedic surgery has been
the standard of care for several decades. Endosseous implantation using
uncemented titanium prostheses is commonly performed in trabecular bone sites
such as the jaws, vertebrae and ileum.
Still, the mechanisms involved in
this fascinating and unique interaction between a living tissue and foreign
substance are poorly understood. An important
reason for the absence of sufficient mechanistic information is the lack of
robust experimental models combined with solid tools to analyze
structurefunction relationships of the implant-bone system.
Qualitative and quantitative ex
vivo analysis of peri-implant tissues is typically done by means of light
microscopy using thin histological sections following implant removal or
thicker ground sections which contain the implant and undecalcified bone. These
techniques are labor-intensive and thus time-consuming.
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