Anaemia affects 24.8% of the population
worldwide. It has wide variety in terms of clinical manifestation of the
disease severity. It can also ranges from almost asymptomatic to severe
haemolytic anaemia. In contrast to all other nucleated cells, RBCs show very
interesting biology.
An alteration in any of the major factors in
RBCs (eg. shape, size, and structural or functional or quantitional
abnormalities in haemoglobin) usually results in compensatory changes in the
other compensatory factors. Sometimes, the compensatory responses may fail
because of severity
of disease or due to underlying pathologic conditions.
The result of failed compensatory responses is
cellular dysfunction, tissue hypoxia and eventual cell death, which ultimately
leads to severity in anaemia and emergency situations due to it. In this paper,
we have concentrated to focus on how the extrinsic and intrinsic defects on
RBCs cause severe haemolytic anaemia, leading to emergencies.
No comments:
Post a Comment